TRPV4 and cancer: As described by Yang et al., TRPV4 is involved in invasive cancer cell motility and, in this context, may promote the formation of membrane protrusions, whereas Mrkonjic et al. showed that a thermo-/osmosensing defective TRPV4 mutant, but not wild-type TRPV4, enhances protrusion formation and cell migration [43,44].