Several rare missense variants in the gene encoding LDL receptor-related protein 6 (LRP6), which plays a crucial role in lipoprotein endocytosis and is an essential co-receptor in the Wnt/ß-catenin signaling pathway (OMIM #603507) [19,20], are linked to metabolic syndrome, high LDL-C levels, and early onset of CVD [21,22,23]. This evidence concerns the gene LRP6 and metabolic syndrome.