Furthermore, we validated DEGs in FOXO3-deficient macrophages, whose role in IBD and colon cancer is not yet well understood, including Stimulated By Retinoic Acid Gene 6 Protein Homolog (STRA6), Serpin Family H Member 1 (SERPINH1), Laminin Subunit Beta 1 (LAMB1), Oxidized Low-Density Lipoprotein Receptor 1 (OLR1), Nuclear Factor, Erythroid 2-like 3 (NFE2L3), DnaJ Heat Shock Protein Family (Hsp40) Member C28 (DNAJC28) and V-Set And Immunoglobulin Domain-containing 10 (VSIG10) (Figure 6A). Here, SERPINH1 is linked to colonic neoplasm.