CDK5 and cancer: We found similarities in pathways and upstream regulators of FOXO3-deficient macrophages with HFD obese mice colon associated with inflammation (IL-1A, IL-1B, IL-6, IL-8 signaling), growth (ILK signaling, CDK5 signaling, VEGF signaling) and cancer (cAMP-mediated signaling) (Figure 1E,F).