SOD1 and amyotrophic lateral sclerosis: Although the contribution of the mitochondrial mutSOD1 aggregates to bioenergetic injuries is still under investigation, a growing body of evidence indicates the aberrant binding of mutSOD1 to voltage-dependent anion channel-1 (VDAC1) as a mechanism that could partially account for the energy deficit described in several SOD1-linked ALS models [75].