While Xu et al. [130] found that the plasma concentrations of neurosecretory protein FGA, c1 inhibitor (C1INH), serum amyloid A(SAA), transthyretin (TTR), hepcidin, apoprotein C III (APoCIII), amyloid precursor protein (APP), cystatin C (CysC), osteopontin (OpN) are significantly decreased in cows with fatty liver, not only proved the mitochondria dysfunction of NAFLD. The gene discussed is APP; the disease is metabolic dysfunction-associated steatotic liver disease.