NPPB and atherosclerosis: Among the 582 replicable associations, we found 62 replicated significant associations involving six ASCVD phenotypes (number of plaques, plaque status, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), carotid intima-media thickness (cIMT), ankle brachial index (ABI) and ABI-based peripheral artery disease status (ABI-PAD)) and 32 metabolites (Table S4 and Figure S3).