These PAF-like molecules can cause oxidative stress by mimicking the inflammatory and thrombotic activities of PAF, which causes platelet aggregation and blood vessel dilation and in turn may lead to thrombosis, as well as to several other thrombo-inflammatory manifestations implicated in endothelial dysfunction, atherosclerosis, CVD, and several tumors [28,29]. This evidence concerns the gene PCLAF and atherosclerosis.