The results of the present study showed a marginal beneficial impact of a polyphenol-rich extract obtained from two algae, Ascophyllum nodosum and Fucus vesiculosus, in the context of moderate weight loss over 12 weeks on metabolic risk factors of type 2 diabetes and cardiovascular disease, namely glucose homeostasis, heart rate, and Il-6 in prediabetic subjects. Here, IL6 is linked to cardiovascular disorder.