Among all individuals cared in GH, 441 women carry at least one PV in the eight genes associated with increased risk for breast cancer (no woman carries STK11 PV in this group; women with neurofibromatosis type 1 is discussed separately), 26 women carrying PVs in more than one gene were categorized under the gene with the highest breast risk, for example, a woman with PVs in BRCA2 and CHEK2 was counted under BRCA2, a woman with PVs in ATM and PMS2 was counted under ATM (Table 1). This evidence concerns the gene BRCA2 and breast cancer.