TYMS and non-small cell lung carcinoma: In contrast, platinum-pemetrexed therapy showed good effectiveness, reflecting a known favorable response to pemetrexed exposure in ROS1-rearranged NSCLC [21,35], postulated to be a result of increased pemetrexed sensitivity due to lower expression of thymidylate synthase among the ROS1-rearranged genotype [21,36].