Pembrolizumab in particular showed a positive effect on ORR (primary endpoint) in PD-L1-positive cancer patients (PD-L1 CPS expression ≥ 1) as compared to PD-L1-negative patients (ORR 15.5% vs. 6.4%, median OS 5.8 vs. 4.6 mths). This evidence concerns the gene CD274 and cancer.