ERBB2 and metastatic neoplasm: For patients with Her2-overexpressing EGC in advanced or metastatic disease stage, the phase II INTEGA trial assesses a superior effect on OS by the chemotherapy-free combination of Her2-blockade (trastuzumab) plus immune checkpoint inhibition (nivolumab + ipilimumab) in comparison with nivolumab plus the standard first-line regimen (trastuzumab + FOLFOX chemotherapy) [40].