BRAF and melanoma: Instead, number of metastatic sites > 2 (HR 2.195, 95%CI 1.302–3.699, p = 0.003), baseline brain metastasis (HR 1.833, 95%CI 1.073–3.130, p = 0.027), and baseline ECOG ≥ 2 (HR 3.957, 95%CI 2.226–7.034, p < 0.001) were significantly associated with worse OS in BRAF-mutant melanoma patients (Table 3).