RB1 and cancer: Besides TP53, the top ten list of mutated cancer associated genes in bladder cancer includes epigenetic regulators KMT2D, KDM6A, ARID1A, KMT2C and EP300, the gene encoding for the catalytic sub-unit alpha of kinase PI3K, PIK3CA, the tumor suppressor RB, the genes encoding for FAT4 cadherin, and for the FGFR3 receptor tyrosine kinase.