The other five highly prevalent mutated genes in bladder cancers, KMT2D, ARID1A, KMT2C, PIK3CA and EP300 (FAT4, although listed as a cancer gene, is not yet curated for functional significance in OncoKB knowledgebase), with difference in prevalence between the high TMB and the low TMB groups, are listed as likely to be oncogenic in 44.4% to 77.8% of cases (Table 2). The gene discussed is PIK3CA; the disease is cancer.