KLK3 and cancer: Working towards the same goal, Bream at al. examined a North American population and concluded that patients with co-existence of a PSA level below 7.5 ng/mL, a Gleason score of 6, a clinical T1c stage and a single biopsy core with cancer occupying less than 1% of tissue could be probably better served with active surveillance instead of RP, unless a repeat biopsy yields more concerning findings [14].