While bromodomain inhibition was not as effective as ATPase inhibition at curbing growth of some SWI/SNF mutant cancers [101], PFI-3, a small molecule selective for the SMARCA4/SMARCA2/PBRM1 bromodomains, sensitized cancer cells to DNA-damaging agents [102,103,104]. The gene discussed is SMARCA4; the disease is cancer.