TFAP2A expression is frequently down-regulated in advanced melanoma [84]; thus, although advanced melanomas may have high levels of SMARCA4, it is conceivable that these melanomas may become de-differentiated and invasive due to failure to target SMARCA4 and the SWI/SNF complex to differentiation-specific loci that are regulated by TFAP2A and MITF. This evidence concerns the gene SMARCA4 and melanoma.