From the perspective of human genetics, somatic and germline mutations in POT1 have been associated with an increased risk for various cancers, including chronic lymphocytic leukemia, Hodgkin lymphoma, colorectal, glioma, melanoma, sarcoma, and angiosarcoma [184,185,186,187,188,189]. Here, POT1 is linked to B-cell chronic lymphocytic leukemia.