Table 12 documents that autologous tumor cell vaccination augmented the HLA-E IgG antibodies in the sera and concomitant reactivity against several allo-HLA-Ia alleles. The allo-HLA-Ia reactivity of HLA-E Abs in the vaccine sera was confirmed by inhibiting the HLA-E and HLA-Ia reactivity of the sera with peptide sequences shared between HLA-E and HLA-Ia alleles [41]. This evidence concerns the gene HLA-E and neoplasm.