Nsp1 is a major virulence factor in SARS-CoV2 which effectively blocks the synthesis of major immune effectors (IFN-β, IFN-λ1, and interleukin-8, retinoic acid–inducible gene I), thereby aiding in establishment of the viral infection (Thoms et al., 2020). Here, IFNB1 is linked to viral infectious disease.