In addition to CC, studies have investigated the association between FOXP3 intron variants and other gynaecological diseases.17, 18 To the best of our knowledge, this was the first study to investigate the associations of rs2294021 and rs3761549 in the FOXP3 gene with susceptibility to HR‐HPV infection and CC malignant lesions. The gene discussed is FOXP3; the disease is female reproductive system disorder.