CHKB and muscular dystrophy: Consistent with the previously reported rostra-caudal pattern of muscular dystrophy, the normalized forelimb muscle weight (triceps) was similar among groups but there was a significant reduction in the normalized hindlimb muscles weights (EDL, gastrocnemius, quadriceps, and TA) in Chkb−/− mice (Fig. 1F) compared to both Chkb+/+ and Chkb+/− mice.