Currently, direct evidence of the correlation between AKAP3 and the PI3K/AKT/mTOR signaling is unavailable, but CTA research in lung cancers has demonstrated the relationship of another cancer-testis antigen LDHC with this signaling, which may promote GSK-3β-dependent phosphorylation of AKT [20]. The gene discussed is AKT1; the disease is lung carcinoma.