In the present study, the results of our in vivo experiments further demonstrated the significantly increased expression levels of the p-AMPK, Beclin1, and Parkin in the heart tissues of DCM model rats after 6 weeks of continuous intervention with APS combined with UTMD compared with saline-treated model control group, and the improvement was more significant relative to APS alone. Here, BECN1 is linked to familial dilated cardiomyopathy.