To sum up, our study demonstrated that miR‐126‐5p inhibited EZH2 to elevate KLF2 expression and reduced BIRC5 expression, all of which leads to the repression of cell proliferation, migration and enhancement of radiosensitivity of lung adenocarcinoma cells and apoptosis (Figure 6F). Here, KLF2 is linked to lung adenocarcinoma.