CNR1 and central nervous system cancer: For example, 2‐AG inhibits the NF‐κB pro‐inflammatory pathway and cell growth via CB1R in human glioma cells (Echigo et al., 2012), and AEA induces apoptosis of human neuroblastoma cells through a CB1R‐dependent pathway via MAPKs and BiP/GRP78, an ER stress sensor that up‐regulates p53 and PUMA (Pasquariello et al., 2009).