CNR1 and central nervous system cancer: Moreover, according to the Chinese Glioma Genome Atlas (http://www.cgga.org.cn), CB1R expression is significantly up‐regulated in IDH‐wild type grade 4 gliomas versus IDH‐mutant grade 4 gliomas (p = 2 × 10−5), while CB2R expression does not change (p = .94).