NR1D1 and Parkinson disease: Since the circadian nuclear receptor REV-ERBα in the ventral tegmental area (VTA) is important for daily mood-related behavior through directly regulating DAergic system [13], we assessed whether the pharmacological administration of a REV-ERBα antagonist (SR8278) [18] into the VTA could change the behavioral symptoms of a PD mouse model in a time-dependent manner.