Particularly noteworthy in context on advanced cSCC, Shapanis et al. reported a significant correlation of poor outcome with increased annexin A5 (ANXA5) and dolichyl-diphosphooligosaccharide-protein glycosyltransferase noncatalytic subunit (DDOST) expression in a retrospective study of patients, which exhibited metastatic disease up to 5 years after primary surgery of cSCC20. The gene discussed is ANXA5; the disease is metastatic neoplasm.