Pathway analysis showed that lncRNA XIST related mRNAs were significantly enriched in 16 pathway terms including ‘PI3K-Akt signaling pathway’, ‘FoxO signaling pathway’, ‘p53 signaling pathway’24 and ‘Ras signaling pathway’, all of which have been shown to play important roles in AML. Here, AKT1 is linked to acute myeloid leukemia.