Moreover, in concordance with our results, the association between autistic traits and X-linked SNPs in the gene family linked with FXS, is likely to be owing to a disruption in the recognition between has-miR-181 and the corresponding seed match sequences in these genes45; miR-181d and FMRP cooperatively regulate the axon elongation process22, 46. Here, FMR1 is linked to fragile X syndrome.