For hsa_circ_0004315, some studies have found that this circRNA may act as a molecular sponge for miRNAs such as hsa-miR-214-3p and hsa-miR-195-5p to regulate the expression, respectively, of PPARGC1A and CCNE1 in hepatocellular carcinoma and breast cancer76,77. This evidence concerns the gene CCNE1 and hepatocellular carcinoma.