Regarding transcripts of the adrenergic pathway, sepsis decreased the α-adrenergic receptor (α-AR) and phospholipase C beta 4 (PLCB4) expression and increased G protein-coupled receptor kinase 5 (GRK5) that inhibits adrenergic pathways, only in OVR females (Table 3 and Supplementary Table 2). The gene discussed is GRK5; the disease is Sepsis.