COL1A1 and liver cancer: Combine our above results with previous studies that mechanical stress promoted the activation of YAP through the integrin protein receptor family (ITGA2/V) [29–31], we hypothesized that TAF-secreted COL1A1 interacts with ITGA2 potentially activated YAP in tumor cells, which possibly contributed to the transcriptional diversity thought enhancing stemness of tumor cells in liver cancer.