Combine our above results with previous studies that mechanical stress promoted the activation of YAP through the integrin protein receptor family (ITGA2/V) [29–31], we hypothesized that TAF-secreted COL1A1 interacts with ITGA2 potentially activated YAP in tumor cells, which possibly contributed to the transcriptional diversity thought enhancing stemness of tumor cells in liver cancer. This evidence concerns the gene ITGA2 and liver cancer.