In co-culture system of ITGA2 knock-down tumor cells and COL1A1 silenced TAFs, the transcription of CTGF and CYR61 was dramatically reduced in ITGA2-depleted cells, whereas, it was elevated in co-cultured with TAFs and markedly decreased after being treated with the COL1A1 inhibitor (Fig. 6L). This evidence concerns the gene CCN1 and neoplasm.