By constructing the PPI network of GSDM family members and their 206 co-expressed genes, we found that EGF, ACAN, POSTN, ATP6V1B1, CDH2, CFTR, CLCNKB, ATP6V0A4, LOX and BSND were mainly related to the modulation and function of the GSDM family differentially expressed in ccRCC. Here, CLCNKB is linked to nonpapillary renal cell carcinoma.