By constructing the PPI network of GSDM family members and their 206 co-expressed genes, we found that EGF, ACAN, POSTN, ATP6V1B1, CDH2, CFTR, CLCNKB, ATP6V0A4, LOX and BSND were mainly related to the modulation and function of the GSDM family differentially expressed in ccRCC. The gene discussed is ACAN; the disease is nonpapillary renal cell carcinoma.