CSS, which is triggered by SARS-CoV-2, involves a variety of inflammatory cytokines such as tumor necrosis factor (TNF), IL-2, IL-6, IL-7, MIP1A, granulocyte colony-stimulating factor, interferon gamma-induced protein 10, and chemokine (CC motif) ligand (CCL) family members [6, 7]; CSS is closely linked to COVID specific ARDS, multi-organ failure, and eventual death [8–10]. The gene discussed is TNF; the disease is acute respiratory distress syndrome.