Taking into account that the oxidation of LDL and the loss of PON-1 antioxidant activity, caused by oxidative stress, are related to atherosclerosis, and that AE and NDGA presented antioxidant activity and prevented lipid peroxidation in macrophages, the effects of AE and NDGA were also studied on HDL and LDL particles subjected to oxidative stress induced by SIN-1 and AAPH. The gene discussed is PON1; the disease is atherosclerosis.