In recent studies, various cancer associated genes were identified to be closely associated with chemo-resistance, for example, overexpression of miR-124 repressed liver CSCs and sorafenib resistance [42], lncRNA NEAT1 contributed to CSC-like properties in CDDP-resistance non-small cell lung cancer cells [43], and MYPT1 downregulation increases platinum resistance in ovarian cancer by increasing the stemness [44]. The gene discussed is PPP1R12A; the disease is cancer.