Besides, the circRNAs/miRNAs axis has been widely been reported to regulate chemo-resistance, for example, Sang et al. report that circRNA_0025202 suppressed tumor progression and sensitivity to tamoxifen through the miR-182-5p/FOXO3a axis in breast cancer [35], and Huang et al. indicate that circAKT3 promotes PI3KR1 expression by sponging miR-198 to elevate the CDDP-resistant properties in gastric cancer [36]. The gene discussed is FOXO3; the disease is breast cancer.