ISM1 and hepatocellular carcinoma: For example, hsa_circ_0091570 serves as a ceRNA sponge for miR-1307 to upregulate ISM1 expression and promotes the progression of hepatocellular cancer [33], and hsa_circ_0074834 boosts osteogenic differentiation of bone nonunion mesenchymal stem cells and bone defect repair through miR-942-5p regulate the expression of VEGF and ZEB1 [34].