ACE2 and COVID-19: The biological rationale for this arises from the understanding that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the viral agent responsible for COVID-19, enters human target cells by binding to the membrane-bound mono-carboxypeptidase—angiotensin-converting enzyme 2 (ACE-2)—resulting in both internalization and degradation of the enzyme [4–6].