In contrast, in the state of obesity, there are changes in the number and activity of various immune cells (e.g., the number of proinflammatory immune cells increases and the number of anti-inflammatory immune cells decreases), which plays a prominent role in the progression of insulin resistance, with the production of several proinflammatory mediators [11, 76]—several of which are components of the inflammatory pathways implicated in insulin resistance, such as TNF-α [94]. The gene discussed is TNF; the disease is Insulin resistance.