CXCL8 and cancer: Its active ingredients may treat GC by regulating the expression of STAT1, MMP9, IL6, HSP90AA1, JUN, CCL2, IFNG, CXCL8, and other targets, activating or inhibiting immune-inflammatory and cancer signaling pathways such as the AGE-RAGE signal pathway, calcium signal pathway, and PI3K/AKT signal pathway, and regulating immune-inflammatory reaction, cell proliferation, differentiation, and apoptosis and antioxidant stress response, etc. Despite the fact that this work gives some theoretical foundation and research suggestions, it still has certain limitations.