STAT3 and cancer: The main active components are sesquiterpenes and diphenyl heptane compounds, which function as antitumor and anodyne [21] mainly through STAT-3, HIF1/ROS, Wnt/β-catenin and Sp-1, cysteine, and other protein apoptosis pathways [22] playing an important role in anticancer of cervical cancer, endometrial cancer, lung cancer, and many other cancers [23].