For example, 6-gingerol could inhibit apoptosis by activating phosphoinositide 3-kinase (PI3K)/Akt pathway and high-mobility group box2 (HMGB2)-c-Jun NH2-terminal kinase1/2 (JNK 1/2)-nuclear factor-kappaB (NF-κB) pathway, thus alleviating myocardial ischemia/reperfusion injury [36, 37]. This evidence concerns the gene HMGB2 and myocardial ischemia.