In consistency, the above findings of PDF-elicited peritoneal fibrosis were associated with GSK3β hyperactivity, marked by increased GSK3β expression and reduced inhibitory phosphorylation of GSK3β at serine 9 residue, as revealed by immunoblot analysis of peritoneal tissues (Figures 2C,D). The gene discussed is GSK3B; the disease is Peritoneal Fibrosis.