FGF21 and hepatocellular carcinoma: While the effect of in vivo administration of FGF21 on autophagy-deficient or -sufficient hepatocellular carcinoma has not been directly investigated, the role of FGF21 in the development of hepatoma has been demonstrated by the high incidence of nonalcoholic steatohepatitis-associated hepatoma after feeding methionine-deficient high-fat diet or high-fat high-sucrose diet in Fgf21-KO mice compared to wild-type mice (16, 17).