SQSTM1 and neoplasm: Regarding the molecular mechanisms of tumor development in autophagy-deficient liver, the roles of genomic damage, accumulation of SQSTM1/p62, an autophagy receptor, inducing activation of KEAP1–NRF2 axis and stabilization of yes-associated protein 1 (YAP1), an effector of the Hippo pathway, have been reported (8–10).