YAP1, as a member of the Hippo signaling pathway, binds to the promoters of target genes such as Areg, Birc5, or Cyr61 in complex with the TEAD transcription factors and would contribute to the initiation or progression of a tumor by regulating cell proliferation, apoptosis susceptibility or cell cycle progression (26, 38). Here, AREG is linked to neoplasm.