In order to analyze LILRB2/PirB’s role in PAD, we created myeloid-specific PirB-null mice (LyzCre/+;PirBflox/flox; Apoe−/−), hereinafter termed PirBMΦKO mice, by crossbreeding LyzCre/+ mice with PirBflox/flox;Apoe−/− mice on a C57Bl/6 background. Here, APOE is linked to peripheral arterial disease.