In this context, Raptis et al. sought to investigate the levels of emerging biomarkers of endothelial function, angiogenesis, and hypoxia, namely, endocan, angiopoietin-1, and hypoxia inducible factor-1a (HF-1a) in ADPKD patients [52]. The gene discussed is ESM1; the disease is autosomal dominant polycystic kidney disease.