HLA-B*46:01-*46:01 (0% vs. 91%, P value = 0.013), DPA1*01:03-*01:03 (7.9% vs. 3.8%, P value = 0.012), and DPB1*02:01-*05:01 (12.0% vs. 20.3%, P value = 0.028) were significantly associated with hypertension. The gene discussed is HLA-DPB1; the disease is hypertensive disorder.