IGHE and Increased total eosinophil count: It usually develops on an atopic background, and it is characterized by eosinophilia, high serum IgE level, and greater filaggrin mutation rate as compared to the intrinsic endotype that exhibits female predominance, delayed onset, as well as lack of atopic background, and is characterized by a relatively more preserved barrier function, normal serum IgE level, and an increased prevalence of metal contact hypersensitivity (Czarnowicki et al., 2019).