Additionally, in a study by Rudel et al, infection of human umbilical vein endothelial cells with Chlamydia trachomatis was found to induce downregulation of P53 mRNA, resulting in decreased protein expression of P53 in the cytoplasm and decreased phosphorylation of DRP1, inhibiting mitochondrial fission; this change was caused by overexpression of miRNA-30c-5p in the host cells (Chowdhury et al., 2017). The gene discussed is TP53; the disease is infection.