On the other hand, chlamydial infection induces activation of the phosphatidylinositol-3-kinase(PI3K)-autologous tumor killing(ATK)-Mdm2 signaling pathway in order to maintain low intracellular P53 levels (Zou et al., 2019), which further limits the activation of DRP1 and results in widespread host cell mitochondrial fusion. The gene discussed is MDM2; the disease is chlamydia trachomatis infectious disease.