TP53 and chlamydia trachomatis infectious disease: On the other hand, chlamydial infection induces activation of the phosphatidylinositol-3-kinase(PI3K)-autologous tumor killing(ATK)-Mdm2 signaling pathway in order to maintain low intracellular P53 levels (Zou et al., 2019), which further limits the activation of DRP1 and results in widespread host cell mitochondrial fusion.