For KCNIP4, its related pathways were regulation of Wnt-mediated β-catenin signaling and target gene transcription (Kitagawa et al., 2007), in which the elevated Wnt-mediated β-catenin signaling could enhance the proliferation of liver cells in HCC (Wang et al., 2019). This evidence concerns the gene KCNIP4 and hepatocellular carcinoma.