PPARGC1A and vitiligo: Yi et al. showed that inhibition of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1-α) and enhanced carbonylation in melanocytes of vitiligo could lead to dysregulation of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase Sirtuin 3 (Sirt3, an enzyme involved in suiting mitochondrial dynamics and homeostasis), which led to mitochondrial severe dysfunction and apoptosis of melanocyte (Yi et al., 2019).