Also, in mice lacking sirtuin 3 (a mitochondrial deacetylase), mitochondrial acetylation is increased and many mitochondrial enzymes and complexes are inhibited, thus inhibiting mitochondrial function and leading to the emergence of spontaneous pulmonary arterial hypertension (PAH) (Paulin et al., 2014). This evidence concerns the gene SIRT3 and pulmonary arterial hypertension.