PRKN and Alzheimer disease: Experiments by David C Schöndorf et al. (Schondorf et al., 2018) showed that the NAD + precursor nicotinamide riboside (NR) can also significantly improve mitochondrial function by increasing mitochondrial autophagy.Targeting mitochondrial Pink1-Parkin-dependent autophagy is a potential therapeutic approach for Alzheimer’s disease (AD).