PPARGC1A and diabetic kidney disease: Recently, a study highlighted that PGC-1α-mediated mitochondrial bioenergetics could play a pivotal role in lipid disorder-induced podocyte injury and the development of DKD, whereas restoring PGC-1α activity and a balanced energy supply via berberine may be a novel therapeutic strategy for the treatment of DKD (Qin et al., 2020).